Serum and milk concentrations of enrofloxacin in cows intramammarily treated with a new enrofloxacin-polymorph

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Therapeutic Review Enrofloxacin

Enrofloxacin is a member of the family of 6-fluoro-7-piperazinyl-4-quinolones.1 This antibiotic is highly lipophilic, and the addition of a carboxic acid and a tertiary amine contributes to the amphoteric properties of enrofloxacin.2 Enrofloxacin is bactericidal and has excellent activity against both Gram-positive and Gram-negative pathogens.1,3 This antibiotic has also been used to control ce...

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The asymmetric unit of the title compound, C19H23FN3O3 (+)·Cl(-)·2H2O [systematic name: 4-(3-carb-oxy-1-cyclo-propyl-6-fluoro-4-oxo-1,4-di-hydro-quin-o-lin-7-yl)-1-ethyl-piperazin-1-ium chloride dihydrate], consists of two independent monocations of the protonated enrofloxacin, two chloride anions and four water mol-ecules. In the cations, the piperazinium rings adopt chair conformations and th...

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ژورنال

عنوان ژورنال: Medycyna Weterynaryjna

سال: 2016

ISSN: 0025-8628

DOI: 10.21521/mw.5587